In the early 20th century, the seminal work of Francisco Tello showed that the CNS has the ability to regenerate itself after an injury. It has been showed that mammalian brains have an endogenous repair system, which sustains tissue homeostasis and repair. This interesting newly opened avenue of research had led to the idea that further dissection of the molecular and cellular events that control the intrinsic brain repair mechanisms might provide an attractive framework for developing more efficacious therapies for neurological diseases. In our lab, we investigated the effects of different transcription factors, Micro RNA and small molecules for enhancing central nervous system endogenous repair.