Regenerative medicine which promises for replacing or regenerating human cells, tissues or organs tries to obtain the required cells from various sources as like as aborted fetal tissues, pluripotent embryonic stem cells or induced pluripotent stem cells, and also transdifferentiation of somatic cells. Transdifferentiation is done based on targeting epigenetic mechanisms, transcription factors and signaling pathways to produce target cells (e.g. oligodendrocyte precursor cells (OPCs). In our lab we work on approaches based on transplantation of stem cells as well as oligodendrocytes that are produced through transdifferentiation of mouse astrocytes or mesenchymal stem, using transcription factors, microRNAs, and small molecules. Additionally, the potency of these newly generated cells for myelin repair will be assessed in experimental models of demyelination.