1. Salimi M, Tabasi F, Abdolsamadi M, Dehghan S, Dehdar K, et al. Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer's disease model. Scientific Reports. 2022;12:1-13.
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2. Pournajaf S, Dargahi L, Javan M, Pourgholami MH. Molecular Pharmacology and Novel Potential Therapeutic Applications of Fingolimod. Frontiers in Pharmacology. 2022;13.
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3. Rayatpour A, Farhangi S, Verdaguer E, Olloquequi J, Ureña J, et al. The cross talk between underlying mechanisms of multiple sclerosis and epilepsy may provide new insights for more efficient therapies. Pharmaceuticals. 2021;14:1031.
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4. Ghamkharinejad G, Marashi SH, Foolad F, Javan M, Fathollahi Y. Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits. PloS one. 2021;16:e0253902.
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5. Poor SR, Ettcheto M, Cano A, Sanchez-Lopez E, Manzine PR, et al. Metformin a potential pharmacological strategy in late onset Alzheimer's disease treatment. Pharmaceuticals. 2021;14:890.
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6. Alipour M, Hajipour-Verdom B, Abdolmaleki P, Javan M. Molecular Properties of Ca2+ Transport Through TRPV2 Channel: A Molecular Dynamic Simulations Study. 2021.
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7. khani Habibabadi F, Sahraian MA, Javan M, Behmanesh M. Fingolimod Regulates BDNF-AS and HOTAIR Expression in Multiple Sclerosis Patients. bioRxiv. 2021.
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8. Rayatpour A, Javan M. Targeting the Brain Lesions Using Peptides: A Review Focused on the Possibility of Targeted Drug Delivery to Multiple Sclerosis Lesions. Pharmacological Research. 2021:105441.
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9. Esmaeilnejad S, Semnanian S, Javan M. Metformin Protects Myelin from Degeneration in A Mouse Model of Iysophosphatidylcholine-Induced Demyelination in The Optic Chiasm. Cell Journal (Yakhteh). 2021;23:119.
10. Dehghan S, Aref E, Raoufy MR, Javan M. An optimized animal model of lysolecithin induced demyelination in optic nerve; more feasible, more reproducible, promising for studying the progressive forms of multiple sclerosis. Journal of Neuroscience Methods. 2021;352:109088.
https://doi.org/10.1016/j.jneumeth.2021.109088
11. Yazdi A, Ghasemi-Kasman M, Javan M. Possible regenerative effects of fingolimod (FTY720) in multiple sclerosis disease: An overview on remyelination process. Journal of Neuroscience Research. 2020;98:524-36.
https://doi.org/10.1002/jnr.24509
12. Sadeghian A, Salari Z, Azizi H, Raoufy MR, Shojaei A, et al. The role of dopamine D<inf>2</inf>-like receptors in a "depotentiation-like effect" of deep brain stimulation in kindled rats. Brain Research. 2020;1738.
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13. Rostami F, Javan M, Moghimi A, Haddad-Mashadrizeh A, Fereidoni M. Prenatal stress promotes icv-STZ-induced sporadic Alzheimer's pathology through central insulin signaling change. Life Sciences. 2020;241.
https://doi.org/10.1016/j.lfs.2019.117154
14. Roshanbakhsh H, Elahdadi Salmani M, Dehghan S, Nazari A, Javan M, et al. Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination. Life sciences. 2020;253:117671.
https://doi.org/10.1016/j.lfs.2020.117671
15. Rezaei S, Dabirmanesh B, Zare L, Golestani A, Javan M, et al. Enhancing myelin repair in experimental model of multiple sclerosis using immobilized chondroitinase ABC I on porous silicon nanoparticles. International Journal of Biological Macromolecules. 2020;146:162-70.
https://doi.org/10.1016/j.ijbiomac.2019.12.258
16. Motavaf M, Sadeghizadeh M, Babashah S, Zare L, Javan M. Dendrosomal nanocurcumin promotes remyelination through induction of oligodendrogenesis in experimental demyelination animal model. Journal of Tissue Engineering and Regenerative Medicine. 2020.
https://doi.org/10.1002/term.3110
17. Kourosh-Arami M, Javan M, Semnanian S. Inhibition of orexin receptor 1 contributes to the development of morphine dependence via attenuation of cAMP response element-binding protein and phospholipase Cβ<inf>3</inf>. Journal of Chemical Neuroanatomy. 2020;108.
https://doi.org/10.1016/j.jchemneu.2020.101801
18. Ghorbani M, Shahabi P, Karimi P, Javan M, Bani S, et al. Sub-threshold electrical stimulation improves winglesstype3 and eukaryotic initiation factor-2α expression in the presence of exogenous astrocyte in the rat model of spinal cord injury. Physiology and Pharmacology (Iran). 2020;24:34-45.
https://doi.org/10.32598/ppj.24.1.30
19. Gholami M, Hosseinmardi N, Mirnajafi-Zadeh J, Javan M, Semnanian S, et al. Long-term potentiation enhancing effect of epileptic insult in the CA1 area is dependent on prior-application of primed-burst stimulation. Experimental Brain Research. 2020;238:897-903.
https://doi.org/10.1007/s00221-020-05766-2
20. Foolad F, Khodagholi F, Nabavi SM, Javan M. Changes in mitochondrial function in patients with neuromyelitis optica; correlations with motor and cognitive disabilities. PLoS ONE. 2020;15.
https://doi.org/10.1371/journal.pone.0230691
21. Pooyan P, Karamzadeh R, Mirzaei M, Meyfour A, Amirkhan A, et al. The Dynamic Proteome of Oligodendrocyte Lineage Differentiation Features Planar Cell Polarity and Macroautophagy Pathways. GigaScience. 2020;9:giaa116.
https://doi.org/10.1093/gigascience/giaa116
22. Pazhoohan S, Aref E, Zare L, Dehghan S, Javan M, et al. Inhibition of Rho-kinase improves response to deep inspiration in ovalbumin-sensitized guinea pigs. Iranian Journal of Basic Medical Sciences. 2020;23:1584.
23. Motavaf M, Sadeghizadeh M, Babashah S, Zare L, Javan M. Protective effects of a nano-formulation of curcumin against cuprizone-induced demyelination in the mouse corpus callosum. Iranian Journal of Pharmaceutical Research. 2020;19:310-20.
24. Zare L, Baharvand H, Javan M. Trichostatin a promotes the conversion of astrocytes to oligodendrocyte progenitors in a defined culture medium. Iranian Journal of Pharmaceutical Research. 2019;18:286-95.
25. Seyedsadr MS, Weinmann O, Amorim A, Ineichen BV, Egger M, et al. Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis. Neurobiology of Disease. 2019;124:189-201.
https://doi.org/10.1016/j.nbd.2018.11.018
26. Sadeghian A, Fathollahi Y, Javan M, Shojaei A, Kosarmadar N, et al. Research paper: Spatial learning and memory in Barnes maze test and synaptic potentiation in Schaffer collateral-CA1 synapses of dorsal hippocampus in freely moving rats. Basic and Clinical Neuroscience. 2019;10:461-8.
https://doi.org/10.32598/bcn.9.10.330
27. Niknam P, Raoufy MR, Fathollahi Y, Javan M. Modulating proteoglycan receptor PTPσ using intracellular sigma peptide improves remyelination and functional recovery in mice with demyelinated optic chiasm. Molecular and Cellular Neuroscience. 2019;99.
https://doi.org/10.1016/j.mcn.2019.103391
28. Khani-Habibabadi F, Askari S, Zahiri J, Javan M, Behmanesh M. Novel BDNF-regulatory microRNAs in neurodegenerative disorders pathogenesis: An in silico study. Computational Biology and Chemistry. 2019;83.
https://doi.org/10.1016/j.compbiolchem.2019.107153
29. Honarvar F, Hojati V, Bakhtiari N, Vaezi G, Javan M. Myelin protection by ursolic acid in cuprizone-induced demyelination in mice. Iranian Journal of Pharmaceutical Research. 2019;18:1978-88.
30. Foolad F, Khodagholi F, Javan M. Sirtuins in Multiple Sclerosis: The crossroad of neurodegeneration, autoimmunity and metabolism. Multiple Sclerosis and Related Disorders. 2019;34:47-58.
https://doi.org/10.1016/j.msard.2019.06.004
31. Farhangi S, Dehghan S, Totonchi M, Javan M. In vivo conversion of astrocytes to oligodendrocyte lineage cells in adult mice demyelinated brains by Sox2. Multiple Sclerosis and Related Disorders. 2019;28:263-72.
https://doi.org/10.1016/j.msard.2018.12.041
32. Dehdar K, Mahdidoust S, Salimi M, Gholami-Mahtaj L, Nazari M, et al. Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit. Scientific Reports. 2019;9.
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33. Zare L, Baharvand H, Javan M. In vivo conversion of astrocytes to oligodendrocyte lineage cells using chemicals: Targeting gliosis for myelin repair. Regenerative Medicine. 2018;13.
https://doi.org/10.2217/rme-2017-0155
34. Yazdi A, Khanghahi AM, Baharvand H, Javan M. Fingolimod enhances oligodendrocyte differentiation of transplanted human induced pluripotent stem cell-derived neural progenitors. Iranian Journal of Pharmaceutical Research. 2018;17:1444-57.
35. Khanghahi AM, Satarian L, Deng W, Baharvand H, Javan M. In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis. PLoS ONE. 2018;13.
https://doi.org/10.1371/journal.pone.0203785
36. Ilka F, Javan M, Raoufy MR. Variable ventilation decreases airway responsiveness and improves ventilation efficiency in a rat model of asthma. Respiratory Physiology and Neurobiology. 2018;255:39-42.
https://doi.org/10.1016/j.resp.2018.05.007
37. Ghasemi-Kasman M, Zare L, Baharvand H, Javan M. In vivo conversion of astrocytes to myelinating cells by miR-302/367 and valproate to enhance myelin repair. Journal of Tissue Engineering and Regenerative Medicine. 2018;12:e462-e72.
https://doi.org/10.1002/term.2276
38. Ghasemi-Kasman M, Shojaei A, Gol M, Moghadamnia AA, Baharvand H, et al. miR-302/367-induced neurons reduce behavioral impairment in an experimental model of Alzheimer's disease. Molecular and Cellular Neuroscience. 2018;86:50-7.
https://doi.org/10.1016/j.mcn.2017.11.012
39. Fathi A, Mirzaei M, Dolatyar B, Sharifitabar M, Bayat M, et al. Discovery of novel cell surface markers for purification of embryonic dopamine progenitors for transplantation in Parkinson's disease animal models. Molecular and Cellular Proteomics. 2018;17:1670-84.
https://doi.org/10.1074/mcp.RA118.000809
40. Eslami-Behroozi M, Javan M, Raoufy MR. Effect of airway remodeling and hyperresponsiveness on complexity of breathing pattern in rat. Respiratory Physiology and Neurobiology. 2018;247:65-70.
https://doi.org/10.1016/j.resp.2017.09.007
41. Emami Aleagha MS, Harirchian MH, Lavasani S, Javan M, Allameh A. Differential Expression of Klotho in the Brain and Spinal Cord is Associated with Total Antioxidant Capacity in Mice with Experimental Autoimmune Encephalomyelitis. Journal of Molecular Neuroscience. 2018;64:543-50.
https://doi.org/10.1007/s12031-018-1058-6
42. Amirifalah Z, Mokhtari-Dizaji M, Javan M. Visual evoked potential frequency content: Effect of lysolecithin induced demyelination in rat optic chiasm. Koomesh. 2018;20:105-14.
43. Rostami F, Javan M, Moghimi A, Haddad-Mashadrizeh A, Fereidoni M. Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model. Life Sciences. 2017;188:172-85.
https://doi.org/10.1016/j.lfs.2017.08.025
44. Pourabdolhossein F, Dehghan S, Demeneix B, Javan M. Nogo receptor blockade enhances subventricular zone's stem cells proliferation and differentiation in demyelination context. Physiology and Pharmacology (Iran). 2017;21:193-205.
45. Pazhoohan S, Raoufy MR, Javan M, Hajizadeh S. Effect of Rho-kinase inhibition on complexity of breathing pattern in a guinea pig model of asthma. PLoS ONE. 2017;12.
https://doi.org/10.1371/journal.pone.0187249
46. Pakravan K, Babashah S, Sadeghizadeh M, Mowla SJ, Mossahebi-Mohammadi M, et al. MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells. Cellular Oncology. 2017;40:457-70.
https://doi.org/10.1007/s13402-017-0335-7
47. Pachenari N, Kiani S, Javan M. Inhibition of glycogen synthase kinase 3 increased subventricular zone stem cells proliferation. Biomedicine and Pharmacotherapy. 2017;93:1074-82.
https://doi.org/10.1016/j.biopha.2017.07.043
48. Namvar S, Fathollahi Y, Javan M, Zeraati M, Mohammad-Zadeh M, et al. The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat. Journal of the Neurological Sciences. 2017;375:450-9.
https://doi.org/10.1016/j.jns.2017.02.047
49. Movaghar B, Tiraihi T, Javan M, Taheri T, Kazemi H. Progesterone-induced transdifferentiation of bone marrow stromal cells into Schwann cells improves sciatic nerve transection outcome in a rat model. Journal of Neurosurgical Sciences. 2017;61:504-13.
https://doi.org/10.23736/S0390-5616.16.02861-7
50. Motavaf M, Sadeghizadeh M, Javan M. Attempts to Overcome Remyelination Failure: Toward Opening New Therapeutic Avenues for Multiple Sclerosis. Cellular and Molecular Neurobiology. 2017;37:1335-48.
https://doi.org/10.1007/s10571-017-0472-6
51. Kashfi S, Peymani M, Ghaedi K, Baharvand H, Esfahani MHN, et al. Purinergic receptor expression and potential association with human embryonic stem cell-derived oligodendrocyte progenitor cell development. Cell Journal. 2017;19:386-402.
52. Kashfi S, Ghaedi K, Baharvand H, Nasr-Esfahani MH, Javan M. A<inf>1</inf> Adenosine Receptor Activation Modulates Central Nervous System Development and Repair. Molecular Neurobiology. 2017;54:8128-39.
https://doi.org/10.1007/s12035-016-0292-6
53. Hooshmand B, Azizi H, Javan M, Semnanian S. Intra-LC microinjection of orexin type-1 receptor antagonist SB-334867 attenuates the expression of glutamate-induced opiate withdrawal like signs during the active phase in rats. Neuroscience Letters. 2017;636:276-81.
https://doi.org/10.1016/j.neulet.2016.10.051
54. Gol M, Ghorbanian D, Hassanzadeh S, Javan M, Mirnajafi-Zadeh J, et al. Fingolimod enhances myelin repair of hippocampus in pentylenetetrazol-induced kindling model. European Journal of Pharmaceutical Sciences. 2017;96:72-83.
https://doi.org/10.1016/j.ejps.2016.09.016
55. Ghasemi-Kasman M, Baharvand H, Javan M. Enhanced neurogenesis in degenerated hippocampi following pretreatment with miR-302/367 expressing lentiviral vector in mice. Biomedicine and Pharmacotherapy. 2017;96:1222-9.
https://doi.org/10.1016/j.biopha.2017.11.094
56. Eslami-Behroozi M, Pazhoohan S, Aref E, Zare L, Javan M, et al. Bronchoconstriction Induces Structural and Functional Airway Alterations in Non-sensitized Rats. Lung. 2017;195:167-71.
https://doi.org/10.1007/s00408-016-9970-4
57. Bayat G, Javan M, Khalili A, Safari F, Shokri S, et al. Chronic endurance exercise antagonizes the cardiac UCP2 and UCP3 protein up-regulation induced by nandrolone decanoate. Journal of Basic and Clinical Physiology and Pharmacology. 2017;28:609-14.
https://doi.org/10.1515/jbcpp-2017-0049
58. Alavian F, Hajizadeh S, Javan M, Bigdeli MR. Effects of preconditioning with intermittent normobaric hyperoxia on TNFR1 and TNFR2 expression in the rat brain. Physiology and Pharmacology. 2017;21:110-9.
59. Moradpour F, Fathollahi Y, Naghdi N, Hosseinmardi N, Javan M. Prepubertal castration-associated developmental changes in sigma-1 receptor gene expression levels regulate hippocampus area CA1 activity during adolescence. Hippocampus. 2016;26:933-46.
https://doi.org/10.1002/hipo.22576
60. Goudarzvand M, Choopani S, Shams A, Javan M, Khodaii Z, et al. Focal injection of Ethidium Bromide as a simple model to study cognitive deficit and its improvement. Basic and Clinical Neuroscience. 2016;7:63-72.
61. Ghafouri S, Fathollahi Y, Javan M, Shojaei A, Asgari A, et al. Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test. Epilepsy Research. 2016;126:37-44.
https://doi.org/10.1016/j.eplepsyres.2016.06.010
62. Dehghan S, Hesaraki M, Soleimani M, Mirnajafi-Zadeh J, Fathollahi Y, et al. Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice. Neuroscience. 2016;318:178-89.
https://doi.org/10.1016/j.neuroscience.2016.01.028
63. Bakhtiari N, Hosseinkhani S, Soleimani M, Hemmati R, Noori-Zadeh A, et al. Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation. Biomedicine and Pharmacotherapy. 2016;78:185-96.
https://doi.org/10.1016/j.biopha.2016.01.010
64. Afhami M, Abbaszadeh F, Saghaei E, Naseri K, Javan M, et al. The demyelination and altered motor performance following electrolytic lesion in the ventrolateral white matter of spinal cord in male rats: Benefit of post-injury administration of estradiol. Physiology and Pharmacology. 2016;20:157-71.
65. Yazdi A, Baharvand H, Javan M. Enhanced remyelination following lysolecithin-induced demyelination in mice under treatment with fingolimod (FTY720). Neuroscience. 2015;311:34-44.
https://doi.org/10.1016/j.neuroscience.2015.10.013
66. Mohajeri M, Sadeghizadeh M, Najafi F, Javan M. Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. Neuropharmacology. 2015;99:156-67.
https://doi.org/10.1016/j.neuropharm.2015.07.013
67. Mohajeri M, Sadeghizadeh M, Javan M. Pertussis toxin promotes relapsing-remitting experimental autoimmune encephalomyelitis in Lewis rats. Journal of Neuroimmunology. 2015;289:105-10.
https://doi.org/10.1016/j.jneuroim.2015.10.012
68. Malakoutikhah M, Satarian L, Kiani S, Javan M. Alpha-Tocopherol increases the proliferation of induced pluripotent stem cell derived neural progenitor cells. Physiology and Pharmacology. 2015;19:90-8.
69. Khezri S, Javan M, Goudarzvand M, Semnanian S, Baharvand H. Dibutyryl cyclic AMP inhibits the progression of experimental autoimmune encephalomyelitis and potentiates recruitment of endogenous neural stem cells. Journal of Molecular Neuroscience. 2015;51:298-306.
https://doi.org/10.1007/s12031-013-9959-x
70. Kaeidi A, Azizi H, Javan M, Soleimani SMA, Fathollahi Y, et al. Direct facilitatory role of paragigantocellularis neurons in opiate withdrawal-induced hyperactivity of rat locus coeruleus neurons: An in vitro study. PLoS ONE. 2015;10.
https://doi.org/10.1371/journal.pone.0134873
71. Ghasemi-Kasman M, Hajikaram M, Baharvand H, Javan M. MicroRNA-mediated in vitro and in vivo direct conversion of astrocytes to neuroblasts. PLoS ONE. 2015;10.
https://doi.org/10.1371/journal.pone.0127878
72. Dokanehiifard S, Soltani BM, Parsi S, Hosseini F, Javan M, et al. Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. Cellular and Molecular Life Sciences. 2015;72:2613-25.
https://doi.org/10.1007/s00018-015-1868-4
73. Dehghan S, Asadi S, Hajikaram M, Soleimani M, Mowla SJ, et al. Exogenous Oct4 in combination with valproic acid increased neural progenitor markers: An approach for enhancing the repair potential of the brain. Life Sciences. 2015;122:108-15.
https://doi.org/10.1016/j.lfs.2014.12.007
74. Bayat G, Javan M, Safari F, Khalili A, Shokri S, et al. Nandrolone decanoate negatively reverses the beneficial effects of exercise on cardiac muscle via sarcolemmal, but not mitochondrial K<inf>ATP</inf> channel. Canadian Journal of Physiology and Pharmacology. 2015;94:324-31.
https://doi.org/10.1139/cjpp-2015-0040
75. Bakhtiari N, Soulemani M, Javan M, Hemmati R, Hosseinkhani S. Ursolic acid induces myoglobin expression and skeletal muscle remodeling in mice. Physiology and Pharmacology. 2015;18:373-82.
76. Azin M, Mirnajafi-Zadeh J, Javan M. Fibroblast growth factor-2 enhanced the recruitment of progenitor cells and myelin repair in experimental demyelination of rat hippocampal formations. Cell Journal. 2015;17:540-6.
77. Asadi S, Dehghan S, Hajikaram M, Mowla SJ, Ahmadiani A, et al. Comparing the effects of small molecules bix-01294, bay k8644, rg-108 and valproic acid, and their different combinations on induction of pluripotency marker-genes by oct4 in the mouse brain. Cell Journal. 2015;16:416-25.
https://doi.org/10.1016/j.lfs.2014.12.007
78. Safari F, Anvari Z, Moshtaghioun S, Javan M, Bayat G, et al. Differential expression of cardiac uncoupling proteins 2 and 3 in response to myocardial ischemia-reperfusion in rats. Life Sciences. 2014;98:68-74.
https://doi.org/10.1016/j.lfs.2013.12.230
79. Pourabdolhossein F, Mozafari S, Morvan-Dubois G, Mirnajafi-Zadeh J, Lopez-Juarez A, et al. Nogo receptor inhibition enhances Functional recovery following lysolecithin-induced demyelination in mouse optic chiasm. PLoS ONE. 2014;9.
https://doi.org/10.1371/journal.pone.0106378
80. Parvini M, Satarian L, Parivar K, Javan M, Tondar M, et al. Human Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium in Retinal Treatment: from Bench to Bedside. Molecular Neurobiology. 2014;50:597-612.
https://doi.org/10.1007/s12035-014-8684-y
81. Nazm Bojnordi M, Movahedin M, Tiraihi T, Javan M, Ghasemi Hamidabadi H. Oligoprogenitor cells derived from spermatogonia stem cells improve remyelination in demyelination model. Molecular Biotechnology. 2014;56:387-93.
https://doi.org/10.1007/s12033-013-9722-0
82. Mousavi Y, Azizi H, Mirnajafi-Zadeh J, Javan M, Semnanian S. Blockade of orexin type-1 receptors in locus coeruleus nucleus attenuates the development of morphine dependency in rats. Neuroscience Letters. 2014;578:90-4.
https://doi.org/10.1016/j.neulet.2014.06.038
83. Hajiasgharzadeh K, Tavangar SM, Javan M, Dehpour AR, Mani AR. Does hepatic vagus nerve modulate the progression of biliary fibrosis in rats? Autonomic Neuroscience: Basic and Clinical. 2014;185:67-75.
https://doi.org/10.1016/j.autneu.2014.07.005
84. Ahmadirad N, Shojaei A, Javan M, Pourgholami MH, Mirnajafi-Zadeh J. Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice. Neurological Sciences. 2014;35:571-6.
https://doi.org/10.1007/s10072-013-1552-0
85. Satarian L, Javan M, Kiani S, Hajikaram M, Mirnajafi-Zadeh J, et al. Engrafted human induced pluripotent stem cell-derived anterior specified neural progenitors protect the rat crushed optic nerve. PloS one. 2013;8.
https://doi.org/10.1371/journal.pone.0071855
86. Pazhoohan S, Satarian L, Asghari AA, Salimi M, Kiani S, et al. Valproic acid attenuates disease symptoms and increases endogenous myelin repair by recruiting neural stem cells and oligodendrocyte progenitors in experimental autoimmune encephalomyelitis. Neurodegenerative Diseases. 2013;13:45-52.
https://doi.org/10.1159/000352021
87. Nazm Bojnordi M, Movahedin M, Tiraihi T, Javan M. Alteration in genes expression patterns during in vitro differentiation of mouse spermatogonial cells into neuroepithelial-like cells. Cytotechnology. 2013;65:97-104.
https://doi.org/10.1007/s10616-012-9465-y
88. Moradpour F, Naghdi N, Fathollahi Y, Javan M, Choopani S, et al. Pre-pubertal castration improves spatial learning during mid-adolescence in rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013;46:105-12.
https://doi.org/10.1016/j.pnpbp.2013.07.005
89. Moradpour F, Fathollahi Y, Naghdi N, Hosseinmardi N, Javan M. Prepubertal castration causes the age-dependent changes in hippocampal long-term potentiation. Synapse. 2013;67:235-44.
https://doi.org/10.1002/syn.21636
90. Mongabadi S, Firoozabadi SM, Javan M, Shojaei A, Mirnajafi-Zadeh J. Effect of different frequencies of repetitive transcranial magnetic stimulation on acquisition of chemical kindled seizures in rats. Neurological Sciences. 2013;34:1897-903.
https://doi.org/10.1007/s10072-013-1401-1
91. Davoudi M, Shojaei A, Palizvan MR, Javan M, Mirnajafi-Zadeh J. Comparison between standard protocol and a novel window protocol for induction of pentylenetetrazol kindled seizures in the rat. Epilepsy Research. 2013;106:54-63.
https://doi.org/10.1016/j.eplepsyres.2013.03.016
92. Azin M, Goudarzvand M, Mirnajafi-Zadeh J, Javan M. Field potential recording from rat hippocampus provides a functional evaluation method for assessing demyelination and myelin repair. Neurological Research. 2013;35:837-43.
https://doi.org/10.1179/1743132813Y.0000000221
93. Asghari AA, Azarnia M, Mirnajafi-Zadeh J, Javan M. Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; Electrophysiological and histopathological studies. Journal of the Neurological Sciences. 2013;325:22-8.
https://doi.org/10.1016/j.jns.2012.11.008
94. Sherafat MA, Heibatollahi M, Mongabadi S, Moradi F, Javan M, et al. Electromagnetic field stimulation potentiates endogenous myelin repair by recruiting subventricular neural stem cells in an experimental model of white matter demyelination. Journal of Molecular Neuroscience. 2012;48:144-53.
https://doi.org/10.1007/s12031-012-9791-8
95. Sadegh M, Fathollahi Y, Javan M, Semnanian S. Tolerance to anti-nociceptive effects of sodium-salicylate and morphine decreases adenosine deaminase activity in the rat hippocampus. Koomesh. 2012;13:390-6.
96. Navidhamidi M, Semnanian S, Javan M, Goudarzvand M, Rohampour K, et al. Examining the effect of the CaMKII inhibitor administration in the locus coeruleus on the naloxone-precipitated morphine withdrawal signs in rats. Behavioural Brain Research. 2012;226:440-4.
https://doi.org/10.1016/j.bbr.2011.09.043
97. Haghani M, Shabani M, Javan M, Motamedi F, Janahmadi M. CB1 cannabinoid receptor activation rescues amyloid β-induced alterations in behaviour and intrinsic electrophysiological properties of rat hippocampal CA1 pyramidal neurones. Cellular Physiology and Biochemistry. 2012;29:391-406.
https://doi.org/10.1159/000338494
98. Dehghan S, Javan M, Pourabdolhossein F, Mirnajafi-Zadeh J, Baharvand H. Basic fibroblast growth factor potentiates myelin repair following induction of experimental demyelination in adult mouse optic chiasm and nerves. Journal of Molecular Neuroscience. 2012;48:77-85.
https://doi.org/10.1007/s12031-012-9777-6
99. Bojnordi MN, Movahedin M, Tiraihi T, Javan M. A simple co-culture system for generation of embryonic stem like cells from testis. Iranian Red Crescent Medical Journal. 2012;14.
https://doi.org/10.5812/ircmj.4051
100. Ali T, Javan M, Sonboli A, Semnanian S. Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models. Natural Product Research. 2012;26:1529-34.
https://doi.org/10.1080/14786419.2011.565284
101. Ali T, Javan M, Sonboli A, Semnanian S. Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats. DARU, Journal of Pharmaceutical Sciences. 2012;20.
https://doi.org/10.1186/2008-2231-20-48
102. Alavian F, Hajizadeh S, Bigdeli MR, Javan M. The role of protein kinase C in ischemic tolerance induced by hyperoxia in rats with stroke. EXCLI Journal. 2012;11:188-97.
103. Alavian F, Hajizadeh S, Bigdeli MR, Bayat GR, Javan M. Evaluation of UCP2 expression in the phenomenon of ischemic resistance induced by alternating normobaric hyperoxia in a rat model of stroke. Physiology and Pharmacology. 2012;16:54-61.
104. Sherafat MA, Javan M, Mozafari S, Mirnajafi-Zadeh J, Motamedi F. Castration attenuates myelin repair following lysolecithin induced demyelination in rat optic chiasm: An evaluation using visual evoked potential, marker genes expression and myelin staining. Neurochemical Research. 2011;36:1887-95.
https://doi.org/10.1007/s11064-011-0510-6
105. Pouya A, Satarian L, Kiani S, Javan M, Baharvand H. Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination. PLoS ONE. 2011;6.
https://doi.org/10.1371/journal.pone.0027925
106. Pourabdolhossein F, Mozafari S, Javan M, Mirnajafi-zadeh J, Ahmadiani A. Electrophysiological and histological study of lysolecithin-induced local demyelination in adult mice optic chiasm. Physiology and Pharmacology. 2011;14:324-36.
107. Mozafari S, Javan M, Sherafat MA, Mirnajafi-Zadeh J, Heibatollahi M, et al. Analysis of structural and molecular events associated with adult rat optic chiasm and nerves demyelination and remyelination; Possible role for 3rd ventricle proliferating cells. NeuroMolecular Medicine. 2011;13:138-50.
https://doi.org/10.1007/s12017-011-8143-0
108. Mahdavi S, Gharibzadeh S, Ranjbar B, Javan M. Voltage-gated sodium channel gating modifiers: Valuable targets for multiple sclerosis treatment. Journal of Neuropsychiatry and Clinical Neurosciences. 2011;23.
https://doi.org/10.1176/appi.neuropsych.23.1.E17
109. Khezri S, Javan M, Baharvand H, Semnanian S. Reaction of subventricular zone stem cells to the induction of experimental autoimmue encephalomyelitis in mouse. Physiology and Pharmacology. 2011;15:229-40.
110. Hosseinmardi N, Azimi L, Fathollahi Y, Javan M, Naghdi N. In vivo sodium salicylate causes tolerance to acute morphine exposure and alters the ability of high frequency stimulation to induce long-term potentiation in hippocampus area CA1. European Journal of Pharmacology. 2011;670:487-94.
https://doi.org/10.1016/j.ejphar.2011.09.008
111. Bayat G, Hajizadeh S, Javan M, Moghadam MF, Safari F, et al. Decreased uncoupling protein 2 and 3 (UCP2 and UCP3) mRNA expression by endurance exercise training with and without chronic administration of nandrolone in rat heart. Physiology and Pharmacology. 2011;15:330-40.
112. Arami MK, Semnanian S, Javan M, Hajizadeh S, Sarihi A. Postnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat. Physiology and Pharmacology. 2011;14:337-48.
113. Zeraati M, Mirnajafi-Zadeh J, Javan M, Semnanian S, Namvar S. Effect of an ectonucleotidase inhibitor on anticonvulsant actions of low-frequency electrical stimulation in perforant path rapid kindling in rats. Physiology and Pharmacology. 2010;14:115-26.
114. Navidhamidi M, Javan M, Fatholahi Y, Semnanian S. Effect of chronic morphine administration on Ca2+/calmodulin- dependent protein kinase IIα activity in rat locus coeruleus and its possible role in morphine dependency. Physiology and Pharmacology. 2010;14:105-14.
115. Namvar S, Mirnajafi-Zadeh J, Javan M, Zeraati M. Alterations of the expression of RGS4 and RGS10 proteins in the anticonvulsant effects of low frequency stimulation on perforant path kindling in adult male rats. Physiology and Pharmacology. 2010;14:234-41.
116. Mozafari S, Sherafat MA, Javan M, Mirnajafi-Zadeh J, Tiraihi T. Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination. Brain Research. 2010;1351:50-6.
https://doi.org/10.1016/j.brainres.2010.07.026
117. Khakpay R, Semnanian S, Javan M, Janahmadi M. Is the pain modulatory action of 17β-estradiol in locus coeruleus of male rats mediated by GABA<inf>A</inf> receptors? Physiology and Pharmacology. 2010;14:252-61.
118. Khakpay R, Semnanian S, Javan M, Janahmadi M. The effect of intra-locus coeruleus injection of 17β-estradiol on inflammatory pain modulation in male rat. Behavioural Brain Research. 2010;214:409-16.
https://doi.org/10.1016/j.bbr.2010.06.012
119. Goudarzvand M, Javan M, Mirnajafi-Zadeh J, Mozafari S, Tiraihi T. Vitamins e and D3 attenuate demyelination and potentiate remyelination processes of hippocampal formation of rats following local injection of ethidium bromide. Cellular and Molecular Neurobiology. 2010;30:289-99.
https://doi.org/10.1007/s10571-009-9451-x
120. Ghorbi J, Javan M, Sheibani V, Zarebkohan A. Changes in beta 1 and beta 2 integrin genes expression in rat lumbar spinal cord is supportive of the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia. Physiology and Pharmacology. 2010;14:94-104.
121. Ghorbi J, Javan M, Sheibani V. Changes in the gene expression of β<inf>1</inf> and β<inf>2</inf> integrins following development of tolerance to analgesic effect of morphine in rats. Yakhteh. 2010;11:448-55.
122. Zarebkohan A, Javan M, Satarian L, Ahmadiani A. Effect of chronic administration of morphine on the gene expression level of sodium-dependent vitamin C transporters in rat hippocampus and lumbar spinal cord. Journal of Molecular Neuroscience. 2009;38:236-42.
https://doi.org/10.1007/s12031-009-9203-x
123. Mohammad-Zadeh M, Mirnajafi-Zadeh J, Fathollahi Y, Javan M, Jahanshahi A, et al. The role of adenosine A<inf>1</inf> receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats. Neuroscience. 2009;158:1632-43.
https://doi.org/10.1016/j.neuroscience.2008.11.008
124. Jahanshahi A, Mirnajafi-Zadeh J, Javan M, Mohammad-Zadeh M, Rohani R. The antiepileptogenic effect of electrical stimulation at different low frequencies is accompanied with change in adenosine receptors gene expression in rats. Epilepsia. 2009;50:1768-79.
https://doi.org/10.1111/j.1528-1167.2009.02088.x
125. Hosseinmardi N, Fathollahi Y, Naghdi N, Javan M. Theta pulse stimulation: A natural stimulus pattern can trigger long-term depression but fails to reverse long-term potentiation in morphine withdrawn hippocampus area CA1. Brain Research. 2009;1296:1-14.
https://doi.org/10.1016/j.brainres.2009.08.020
126. Hosseinmardi N, Azimi L, Javan M, Naghdi N, Fathollahi Y. Augmentation of paired pulse index as short-term plasticity due to morphine dependence. Physiology and Pharmacology. 2009;13:108-19.
127. Asadi S, Javan M, Ahmadiani A, Sanati MH. Alternative splicing in the synaptic protein interaction site of rat Ca<inf>v</inf>2.2 (α<inf>1B</inf>) calcium channels: Changes induced by chronic inflammatory pain. Journal of Molecular Neuroscience. 2009;39:40-8.
https://doi.org/10.1007/s12031-008-9159-2
128. Satarian L, Javan M, Fathollahi Y. Epinephrine inhibits analgesic tolerance to intrathecal administrated morphine and increases the expression of calcium-calmodulin-dependent protein kinase IIα. Neuroscience Letters. 2008;430:213-7.
https://doi.org/10.1016/j.neulet.2007.10.038
129. Jalalvand E, Javan M, Haeri-Rohani A, Ahmadiani A. Stress- and non-stress-mediated mechanisms are involved in pain-induced apoptosis in hippocampus and dorsal lumbar spinal cord in rats. Neuroscience. 2008;157:446-52.
https://doi.org/10.1016/j.neuroscience.2008.08.052
130. Jahanshahi A, Mirnajafi-Zadeh J, Javan M, Mohammad-Zadeh M, Rohani R. Effect of low-frequency stimulation on adenosine A<inf>1</inf> and A <inf>2A</inf> receptors gene expression in dentate gyrus of perforant path kindled rats. Yakhteh. 2008;10:87-92.
131. Esmaeili-Mahani S, Shimokawa N, Javan M, Maghsoudi N, Motamedi F, et al. Low-dose morphine induces hyperalgesia through activation of G <inf>αs</inf>, protein kinase C, and L-type Ca2+ channels in rats. Journal of Neuroscience Research. 2008;86:471-9.
https://doi.org/10.1002/jnr.21489
132. Esmaeili-Mahani S, Javan M, Motamedi F, Ahmadiani A. Post-adrenalectomy changes in the gene expression of specific G-protein subunits involved in morphine sensitization. Neuropeptides. 2008;42:169-75.
https://doi.org/10.1016/j.npep.2007.12.002
133. Amini H, Javan M, Gazerani P, Ghaffari A, Ahmadiani A. Lack of bioequivalence between two aciclovir tablets in healthy subjects. Clinical Drug Investigation. 2008;28:47-53.
https://doi.org/10.2165/00044011-200828010-00006
134. Sadegh M, Mirnajafi-Zadeh J, Javan M, Fathollahi Y, Mohammad-Zadeh M, et al. The role of galanin receptors in anticonvulsant effects of low-frequency stimulation in perforant path-kindled rats. Neuroscience. 2007;150:396-403.
https://doi.org/10.1016/j.neuroscience.2007.09.068
135. Mohammad-Zadeh M, Mirnajafi-Zadeh J, Fathollahi Y, Javan M, Ghorbani P, et al. Effect of low frequency stimulation of perforant path on kindling rate and synaptic transmission in the dentate gyrus during kindling acquisition in rats. Epilepsy Research. 2007;75:154-61.
https://doi.org/10.1016/j.eplepsyres.2007.05.003
136. Jamali A, Mahdavi M, Shahabi S, Hassan ZM, Sabahi F, et al. Naloxone, an opioid receptor antagonist, enhances induction of protective immunity against HSV-1 infection in BALB/c mice. Microbial Pathogenesis. 2007;43:217-23.
https://doi.org/10.1016/j.micpath.2007.06.001
137. Fereidoni M, Javan M, Semnanian S, Ahmadiani A. Chronic forced swim stress inhibits ultra-low dose morphine-induced hyperalgesia in rats. Behavioural Pharmacology. 2007;18:667-72.
https://doi.org/10.1097/FBP.0b013e3282f007cb
138. Esmaeili-Mahani S, Fereidoni M, Javan M, Maghsoudi N, Motamedi F, et al. Nifedipine suppresses morphine-induced thermal hyperalgesia: Evidence for the role of corticosterone. European Journal of Pharmacology. 2007;567:95-101.
https://doi.org/10.1016/j.ejphar.2007.03.042
139. Shahabi S, Hashemi M, Hassan ZM, Javan M, Bathaie SZ, et al. The effect of post-burn local hyperthermia on the reducing burn injury: The possible role of opioids. International Journal of Hyperthermia. 2006;22:421-31.
https://doi.org/10.1080/02656730600841857
140. Javan M, Kazemi B, Ahmadiani A, Motamedi F. Dexamethasone mimics the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia and compensates for morphine induced changes in G proteins gene expression. Brain Research. 2006;1104:73-9.
https://doi.org/10.1016/j.brainres.2006.05.088
141. Amini H, Javan M, Ahmadiani A. Development and validation of a sensitive assay of valproic acid in human plasma by high-performance liquid chromatography without prior derivatization. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2006;830:368-71.
https://doi.org/10.1016/j.jchromb.2005.11.028
142. Javan M, Ahmadiani A, Motamadi F, Kazemi B. Changes in G proteins genes expression in rat lumbar spinal cord support the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia. Neuroscience Research. 2005;53:250-6.
https://doi.org/10.1016/j.neures.2005.06.020
143. Farazifard R, Safarpour F, Sheibani V, Javan M. Eye-wiping test: A sensitive animal model for acute trigeminal pain studies. Brain Research Protocols. 2005;16:44-9.
https://doi.org/10.1016/j.brainresprot.2005.10.003
144. Esmaeili Mahani S, Motamedi F, Javan M, Ahmadiani A. Involvement of hypothalamic pituitary adrenal axis on the effects of nifedipine in the development of morphine tolerance in rats. Pharmacology Biochemistry and Behavior. 2005;81:152-7.
https://doi.org/10.1016/j.pbb.2005.03.004
145. Ahmadiani A, Javan M, Semnanian S, Barat E, Kamalinejad M. Anti-inflammatory and antipyretic effects of Trigonella foenum-graecum leaves extract in the rat. Journal of Ethnopharmacology. 2001;75:283-6.
https://doi.org/10.1016/S0378-8741(01)00187-8
146. Fereidoni M, Ahmadiani A, Semnanian S, Javan M. An accurate and simple method for measurement of paw edema. Journal of Pharmacological and Toxicological Methods. 2000;43:11-4.
https://doi.org/10.1016/S1056-8719(00)00089-7
147. Ahmadiani A, Hosseiny J, Semnanian S, Javan M, Saeedi F, et al. Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. Journal of Ethnopharmacology. 2000;72:287-92.
https://doi.org/10.1016/S0378-8741(00)00222-1
148. Javan M, Ahmadiani A, Semnanian S, Kamalinejad M. Antinociceptive effects of Trigonella foenum-graecum leaves extract. Journal of Ethnopharmacology. 1997;58:125-9.
https://doi.org/10.1016/S0378-8741(97)00089-5